ePath
Essential Gene Prediction and Database
Dr. Xu's lab
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Search prediction database
Example
Search by organism name
Streptococcus sanguinis
or
Escherichia coli
K-12 MG1655
Search by organism then by gene locus
Streptococcus sanguinis
or
Escherichia coli
K-12 MG1655 then SSA_0001, or eco:b0002
Search by organism then by KO#
Streptococcus sanguinis
or
Escherichia coli
K-12 MG1655 then K00001, or K02313
Search by organism then by gene name
Streptococcus sanguinis
or
Escherichia coli
K-12 MG1655 then purL or dnaK
Search experiment database
Example
Search by organism name
Streptococcus sanguinis
or
Escherichia coli
K-12 MG1655
Search by organism then by gene locus
Streptococcus sanguinis
or
Escherichia coli
K-12 MG1655 then SSA_0001, or eco:b0002
Search by organism then by KO#
Streptococcus sanguinis
or
Escherichia coli
K-12 MG1655 then K00760, or K02313
Search by organism then by g
ene name
Streptococcus sanguinis
or
Escherichia coli
K-12 MG1655 then purL or dnaK
Notes:
Essentiality scores
Two types of scores based on either experiments (E_score) or prediction (P_score). Genes with higher scores are more likly to be essential. The threshold for essential genes is E_score >0.6 and P_score 0.03.
Note
: If a paralog, isozyme or conditionally essential gene is present, a predicted essential gene with a high score may NOT be successfully deleted in a single gene knockout experiment.