ePath Essential Gene Prediction and DatabaseDr. Xu's lab

Search prediction database

Example

Search by organism nameStreptococcus sanguinis or Escherichia coli K-12 MG1655
Search by organism then by gene locusStreptococcus sanguinis or Escherichia coli K-12 MG1655 then SSA_0001, or eco:b0002
Search by organism then by KO#Streptococcus sanguinis or Escherichia coli K-12 MG1655 then K00001, or K02313
Search by organism then by gene nameStreptococcus sanguinis or Escherichia coli K-12 MG1655 then purL or dnaK

Search experiment database

Example

Search by organism nameStreptococcus sanguinis or Escherichia coli K-12 MG1655
Search by organism then by gene locusStreptococcus sanguinis or Escherichia coli K-12 MG1655 then SSA_0001, or eco:b0002
Search by organism then by KO#Streptococcus sanguinis or Escherichia coli K-12 MG1655 then K00760, or K02313
Search by organism then by gene nameStreptococcus sanguinis or Escherichia coli K-12 MG1655 then purL or dnaK

Notes:

Essentiality scoresTwo types of scores based on either experiments (E_score) or prediction (P_score). Genes with higher scores are more likly to be essential. The threshold for essential genes is E_score >0.6 and P_score 0.03.
Note
: If a paralog, isozyme or conditionally essential gene is present, a predicted essential gene with a high score may NOT be successfully deleted in a single gene knockout experiment.